Boothroyd Lab In the Department of Microbiology & Immunology

 

Current Group


Name

Position/Degree

Project

John Boothroyd

Professor

Ph.D. (Edinburgh)

1979

The overall goal of the lab is to understand how does Toxoplasma infect and persist within a huge number of warm-blooded hosts and why does the outcome of that infection range from essentially no symptoms at all through to fatal encephalitis?

Lidia Barouh

Research Technician

B.Sc.

Lab support.

 

Nicole Blackburn

Grad. Student

B.A. (Rice)

2011

What triggers release of rhoptry proteins during invasion? [Something must trigger rhoptries to inject their contents into the host cell but the stimuli and signal transduction machinery for this are unknown.]

Kerry Buchholz

Post-doc

Ph.D. (Berkeley)

2007

How do secreted proteins facilitate bradyzoite invasion and persistence?  [Secreted proteins are presumed key to bradyzoite invasion and growth just as they are for tachyzoites but they are much less studied in this stage of asexual growth.]

Sarah Ewald

Post-doc

Ph.D. (Berkeley)

2010

What drives the innate immune response to Toxoplasma infection?  [Infection is rapidly detected by the host by means that are poorly understood.]

Pascale Guiton

 

Post-doc

Ph.D. (Washington University)

2012

How do sporozoites, the product of sexual reproduction of Toxoplasma, co-opt host cell functions to initiate an infection in a new intermediate host? [Sporozoites express a very different arsenal of secreted proteins many of which are expected to serve as "effectors" that alter host cell function in ways beneficial to the invading parasite.]
Felice Kelly Post-doc

Ph.D. (Rockefeller)

2011

How are rhoptry proteins injected into the host cell? [Rhoptries are the source of the proteins that Toxoplasma uses to co-opt host functions but how the rhoptry contents are introduced into the host cell, which involves crossing three membranes[!], is not known.]

Margaret Nakamoto Grad. Student

BA (University of Pennsylvania)

2009

What is the role of pseudouridine synthase in the differentiation of tachyzoites into bradyzoites? [A screen for mutants with a defect in asexual differentiation identified a gene encoding a pseudouridine synthase - an enzyme that catalyzes the conversion of uridines to pseudouridines in RNA - as crucial but how such modifications impact differentiation is a complete mystery.]
Adit Naor Post-doctoral Fellow

PhD (Tel Aviv)

2014

What makes the infectious protozoan Toxoplasma gondii such an extraordinary generalist? [Identification of host  specific genes and adaptation to different hosts] 
Michael Panas Post-doc

PhD (Harvard)

2012

How do tachyzoites down-regulate the immune response?  [Tachyzoites somehow block ability of interferon-gamma to up-regulate the expression of MHC class II on the surface of infected cells.]

Suchita Rastogi

Graduate Student

B.A. (Washington Univ)

2012

Identifying the machinery employed by Toxoplasma gondii to inject effector proteins into host cells

 

 

 

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